Anthony Joshua on Saturday night, lost his IBF, WBA and WBO belts in a stunning fight at the Tottenham Hotspur Stadium.
Usyk defeated Joshua by a unanimous decision.
The judges’ result sheets read: 117-112, 116-112 and 115-113.
The Ukranian’s speed and skill proved to be too much for Joshua, who was saved by the bell.
Joshua was badly hurt in the third round and carried a swelling injury on his right eye at the end of the fight.
This is the second defeat of his career, after he was upset by Andy Ruiz Jr in 2019.
Tonight’s loss will now throw a spanner into the works of an undisputed title fight against Tyson Fury, who again faces Deontay Wilder on October 9.
Usyk becomes the only third boxer (after Evander Holyfield and David Haye) to win world titles at cruiserweight and heavyweight.